The Article: Hypothermia after Cardiac Arrest Study Group. “Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest.” N Engl J Med2002.346 (2002): 549-556.
The Idea: Several animal studies prior to this randomized controlled trial had shown that moderate systemic hypothermia or mild hypothermia markedly mitigated brain damage after cardiac arrest in dogs. Prior to hypothermic therapy, there was no therapy with documented efficacy in preventing brain damage after cardiac arrest.
The Study: In this multicenter trial with blinded assessment of the ...Continue Reading →