The Article: Hayward, Gail Nicola, et al. “Effect of Oral Dexamethasone Without Immediate Antibiotics vs Placebo on Acute Sore Throat in Adults: A Randomized Clinical Trial.” Jama 317.15 (2017): 1535-1543.
The Idea: Compare oral dexamethasone versus placebo to determine if one-time dose of 10mg dexamethasone in the primary care setting can result in total resolution of symptoms at 24 or 48 hours. Key metric was complete resolution at 24 hours with complete resolution at 48 hours as a secondary outcome.
The Study: Adult primary ...Continue Reading →